Comparison of Uroplakin Expression During Urothelial Carcinogenesis Induced by N-Butyl-N-(4-Hydroxybutyl)Nitrosamine in Rats and Mice
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منابع مشابه
N - Butyl - N - ( 4 - Hydroxybutyl ) Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis Induced
http://tpx.sagepub.com/content/27/6/645 The online version of this article can be found at: DOI: 10.1177/019262339902700606 1999 27: 645 Toxicol Pathol Cohen Kumiko Ogawa, Margaret St. John, Maria Luiza De Oliveira, Lora Arnold, Tomoyuki Shirai, Tung-Tien Sun and Samuel M. N-Butyl-N-(4-Hydroxybutyl)Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis ...
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The bladder is an important organ for the storage of excreted water and metabolites. If metabolites with carcinogenic characteristics are present in urine, the urothelial lining of the bladder could be damaged and genetically altered. In this study, we analyzed the interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) on mouse bladder carcinogenesis. Our previous study found th...
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Bladder cancer is estimated to be the ninth most common malignancy with a high rate of recurrence and progression despite therapy, early diagnosis being crucial for timely intervention. Using a well-established animal model of urothelial carcinoma, we performed a comprehensive analysis of urine proteome profile from healthy animals and animals with urothelial carcinoma at two time-points of dis...
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The histological background for multifocal and metachronous development of urothelial carcinomas remains equivocal, although accumulated genetic evidence suggests monoclonal origin of multiple urothelial carcinomas. Clonal development of various preneoplastic and neoplastic urothelial lesions of C3H<-->BALB/c chimeric mice induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was immunohistoch...
متن کاملInhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea.
BACKGROUND Recently, the anticarcinogenic effects of green tea have been studied in sites other than the urinary tract. The present study examined the inhibition by green tea of vesical tumors induced in rats by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). METHODS In the first series of experiments, 0.05% BBN was added to the drinking water of rats and remained present for 5 weeks. In one ex...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1999
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339902700606